We have recently generated a novel medulloblastoma (MB) mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1+-Tis21KO).ts main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs).By genomic Gas Cylinder Adaptor analysis of GCPs in vivo, we identified as drug target and major re

David Boyer,1 K Bailey Freund,2 Carl Regillo,3 Marc H Levy,4 Sumit Garg5 1Retina-Vitreous Associates Medical Group, Beverly Hills, CA, 2Vitreous-Retina-Macula Consultants of New York, New York, NY; 3Wills Eye Institute, Philadelphia, PA, 4Sarasota Retina Institute, Sarasota, FL, 5The Gavin Herbert Eye Institute (University of California, Irvine) Ir

Abstract The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.These three types of cells establish complex signals in the body and further influence tumor genesis, development, metastasis and

Background:.Appropriate management of soft tissue injury associated with orthopedic trauma is challenging in low- and middle-income countries (LMICs) due to the lack of available reconstructive surgeons.The Surgical Management and Reconstructive Training (SMART) course teaches orthopedic surgeons reconstructive techniques aimed at improving soft ti

Bahan bakar merupakan salah satu kebutuhan yang saat ini tidak bisa dilepaskan dari masyarakat.Bahan bakar cair terutama bensin atau premium, pertalite, pertamax, dan solar merupakan bahan bakar yang digunakan pada alat transportasi.Semakin banyak alat transportasi yang dimiliki masyarakat dapat memungkinkan tidak tersedianya stok bahan bakar di sa